A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies and anaphylaxis.

Pheniramine maleate is a medicine used to treat allergic conditions such as hayfever, runny nose, itching skin and skin rashes. It is also used in the prevention and treatment of nausea, vomiting, and dizziness due to inner ear disorders (eg Meniere's disease) and travel sickness.

Desloratadine is a tricyclic H₁ antagonist that is used to treat allergies. It is an active metabolite of loratadine.

Diphenhydramine is an antihistamine mainly used to treat allergies. It can also be used for insomnia, symptoms of the common cold, tremor in parkinsonism and nausea.