Pharmaceutical Ingredients

Mannogem AG Granular Mannitol USP/EP has a larger particle size that has shown to contribute to a softer texture for chewable tablets.

Mannogem Mannitol Powder is an excellent tablet diluent/ filler for use in wet granulation and lyophilization. It dries rapidly, resulting in shorter processing time and increased productivity. Mannitol is also a good excipient for hot melt extrusion applications. It melts without decomposition at a temperature of approximately 165° C. Its rapid recrystallization upon cooling make it an attractive carrier to improve solubility of poorly soluble APIs.

The proprietary process used to manufacture Mannogem EZ Spray Dried - Mannitol yields a porous material with lower disintegration times, a narrow particle size distribution, enhanced flow, and compression properties. It is due to these properties that Mannogem EZ is excellent in ODT formulations. It produces tablets with higher hardness than other excipients at comparable compression forces, and its higher surface area allows Mannogem EZ to work well as a base for ordered mixing with micronized APIs and low dose formulations. Mannogem® Mannitol products are manufactured from sugar cane or from corn starch/syrup.

Lubripharm Sodium Stearyl Fumarate (SSF) is an inert, less hydrophobic alternative to magnesium stearate as a pharmaceutical tablet lubricant. Tablets made with Lubripharm SSF exhibit less sensitivity to variations in blending time and lubricant levels and have functionally superior hardness characteristics compared to tablets produced with magnesium stearate. In addition, Lubripharm SSF does not exhibit incompatibility with active pharmaceutical ingredients (APIs) that are susceptible to oxidation or degradation in alkaline conditions or contain primary amines. Lubripharm® SSF is manufactured from natural and synthetic sources; no animal products are used.