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Extended-Release Tablet

Components:

  1. Active Pharmaceutical Ingredient (API): The drug itself, such as metformin in a diabetes medication.
  2. Polymers: Substances that control the release rate of the drug, such as hydroxypropyl methylcellulose (HPMC).
  3. Fillers: Inert substances that help make up the tablet’s bulk, like microcrystalline cellulose.
  4. Binders: Agents that help hold the tablet together, such as polyvinylpyrrolidone (PVP).
  5. Disintegrants: Substances that help the tablet break down in the digestive system, such as croscarmellose sodium.
  6. Lubricants: Materials that prevent the tablet ingredients from sticking to manufacturing equipment, like magnesium stearate.

Formulation Process:

  1. Blending: The API is mixed with excipients (inactive components) to achieve a uniform distribution.
  2. Granulation: The blend is granulated to form granules that improve flowability and compressibility.
  3. Compression: Granules are compressed into tablet form, creating the extended-release matrix.
  4. Coating: Tablets may be coated to control release, protect the API, or improve appearance.

Benefits:

  • Improved Compliance: Patients take fewer doses, leading to better adherence to the medication regimen.
  • Stable Drug Levels: Consistent drug levels in the bloodstream reduce peaks and troughs, potentially improving efficacy and reducing side effects.
  • Convenience: Extended-release formulations often require only once-daily dosing.

Significance: This formulation example highlights how pharmaceutical science aims to enhance the effectiveness and convenience of medications by designing drug delivery systems that improve patient outcomes and compliance.

La quantità del prodotto è stata aggiornata.