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Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes and runny nose. Loratadine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching and other cold or allergy symptoms.

Pheniramine maleate is a medicine used to treat allergic conditions such as hayfever, runny nose, itching skin and skin rashes. It is also used in the prevention and treatment of nausea, vomiting, and dizziness due to inner ear disorders (eg Meniere's disease) and travel sickness.

Desloratadine is a tricyclic H₁ antagonist that is used to treat allergies. It is an active metabolite of loratadine.

Diphenhydramine is an antihistamine mainly used to treat allergies. It can also be used for insomnia, symptoms of the common cold, tremor in parkinsonism and nausea.