Tacrolimus is an immunosuppressive drug. It is used after allogeneic organ transplant to lower the risk of organ rejection and also as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis.
Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments and eyedrops. Neomycin belongs to aminoglycoside class of antibiotics that contain two or more amino sugars connected by glycosidic bonds.
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.