Excipients

The proprietary process used to manufacture Mannogem EZ Spray Dried - Mannitol yields a porous material with lower disintegration times, a narrow particle size distribution, enhanced flow, and compression properties. It is due to these properties that Mannogem EZ is excellent in ODT formulations. It produces tablets with higher hardness than other excipients at comparable compression forces, and its higher surface area allows Mannogem EZ to work well as a base for ordered mixing with micronized APIs and low dose formulations. Mannogem® Mannitol products are manufactured from sugar cane or from corn starch/syrup.

Pharmaburst ® C1 a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols, a supplemental sugar alcohol, a supplemental flow agent, and a supplemental disintegrant.

Advantol® is a robust, off-the-shelf excipient system that allows the formulator fast product development. It requires no special manufacturing equipment or tooling. Simply add the active to Advantol, dry blend and compress.

Mannogem AG Granular Mannitol USP/EP has a larger particle size that has shown to contribute to a softer texture for chewable tablets.